Publications


A.L. Sanborn*, S.S.P. Rao*, S.C. Huang, N.C. Durand, M.H. Huntley, A.I. Jewett, I.D. Bochkov, D. Chinnappan, A. Cutkosky, J. Li, K.P. Geeting, A. Gnirke, A. Melnikov, D. McKenna, E.K. Stamenova. E.S. Lander, E. Lieberman Aiden. (2015) Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. Proceedings of the National Academy of Sciences 112(47).

Featured in over 20 international media outlets, including TIME, Science, The Atlantic, Science News, Houston Chronicle (front page), Baylor, and Rice University; and congratulated on the floor of the US House of Representatives. Our highlights video won the 2016 Lab Grammies!



L. Vian*, A. Pekowska*, S. Rao*, K. Kieffer-Kwon*, S. Jung*, L. Baranello, S. Huang, L. El Khattabi, M. Dose, N. Pruett, A.L. Sanborn, and A. Canela, Y. Maman, A. Oksanen, W. Resch, X. Li, B. Lee, A. Kovalchuk, Z. Tang, S. Nelson, M. Di Pierro, R. Cheng, I. Machol, B. St Hilaire, N. Durand, M. Shamim, E. Stamenova, J. Onuchic, Y. Ruan, A. Nussenzweig, D. Levens, E. Lieberman Aiden, R. Casellas. (2018). The energetics and physiological impact of cohesin extrusion. Cell, 173, 1-14.



S. Rao, S. Huang, B. St Hilaire, J. Engreitz, E. Perez, K. Kieffer-Kwon, A.L. Sanborn, S. Johnstone, G. Bascom, I. Bochkov, X. Huang, M. Shamim, J. Shin, D. Turner, Z. Ye, A. Omer, J. Robinson, T. Schlick, B. Bernstein, R. Casellas, E. Lander, and E. Lieberman Aiden. (2017). Cohesin loss eliminates all loop domains. Cell, 171(2). 



E. Darrow*, M. Huntley*, O. Dudchenko, E. Stamenova, N. Durand, Z. Sun, S. Huang, A.L. Sanborn, I. Machol, M. Shamim, A. Seberg, E. Lander, B. Chadwick, E. Lieberman Aiden. (2016). Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture. PNAS, 113(31).




W. Huang*, A. Manglik*, A.J. Venkatakrishnan, T. Laeremans, E. Feinberg, A.L. Sanborn, H. Kato, K Livingston, T. Thorsen, R. Kling, S. Granier, P. Gmeiner, J. Traynor, W. Weis, J. Steyaert, R. Dror, B. Kobilka. (2015) Structural insights into mu-opioid receptor activation. Nature, 524(7565), 315-321.





S. Rao*, M. Huntley*, N. Durand, E. Stamenova, I. Bochkov, J. Robinson, A.L. Sanborn, I. Machol, A. Omer, E. Lander, E. Lieberman Aiden. (2014) A 3D map of the human genome at kilobase resolutionreveals principles of chromatin looping. Cell 159(7), 1665-1680. 

Featured in over 60 international media outlets, including NPR, Science, NIH blog, KQED, Science News, Houston Chronicle, Broad Institute, Harvard, and Baylor. Our paperflick won the 2015 Lab Grammies!



A.L. Sanborn. Scaling Dimensions with Fractal Curves and Applications to DNA Folding. (Undergraduate thesis, Harvard University, 2011.)

Presented at the Joint Mathematics Meetings in January 2011 and 2014 and at the American Physical Society Annual meeting in 2012. Advised by Erez Lieberman Aiden and Sarah Koch.



K. Carde*, J. Loubert*, A. Potechin*, A.L. Sanborn*. Proof of Han’s hook expansion conjecture. arXiv:0808.0928 (2008).