I am a Ph.D. student at Stanford University in the lab of Roger Kornberg, where I study mechanisms of transcriptional regulation. I also work closely with Erez Lieberman Aiden to study higher-order 3D genome organization.

My research explores how the two-meter-long human genome folds inside the microscopic nucleus of a cell. We showed that a cell folds its DNA into loops and domains which define a specific 3D landscape for distal gene regulation. I developed a mechanistic model for how chromatin forms these higher-order structures through a process of loop extrusion. This model uses molecular dynamics simulations to explain how the genome folds and predict how the fold will change upon editing the DNA, allowing us now to engineer genomes in 3D. We have extended this model to explain genome compartmentalization and X-chromosome inactivation.

graduated from Harvard in 2011 where I majored in mathematics and minored in computer science. My thesis derived a novel symmetry - that fractal curves linearly transform the dimension of all subsets. I also completed a masters degree in 2014 at New England Conservatory where I studied flute with Paula Robison.

Contact: asanborn <at> stanford.edu