I am a computer science Ph.D. student at Stanford University in the lab of Roger Kornberg, where I develop new biotechnologies to study mechanisms of transcriptional regulation in human and yeast cells. My work spans many disciplines, including genomics, molecular biology, biochemistry, machine learning, bioinformatics, and molecular simulation. I was an Accel Innovation Scholar (2018-19) and a NDSEG Fellowship winner (2015-18)

I have also worked closely with Erez Lieberman Aiden to study how the two-meter-long human genome folds inside the microscopic nucleus of a cell. We showed that a cell folds its DNA into loops and domains which define a specific 3D landscape for distal gene regulation. I developed a mechanistic model for how chromatin forms these higher-order structures through a process of loop extrusion. This model uses molecular dynamics simulations to explain how the genome folds and predict how the fold will change upon editing the DNA, allowing us now to engineer genomes in 3D.

I did my undergrad at Harvard where I majored in mathematics and minored in computer science. I also completed a masters degree at New England Conservatory where I studied flute performance with Paula Robison.

Contact: asanborn <at> stanford.edu