I am a Ph.D. student in Computer Science at Stanford University, focusing on computational biology. I work primarily with Erez Lieberman Aiden, Roger Kornberg, and Ron Dror.
My research explores how the two-meter-long human genome folds inside the microscopic nucleus of a cell. We showed that a cell packages its DNA into loops and domains that turn genes on or off. I developed a model for how chromatin forms these higher-order structures through a process of loop extrusion. This model explains how the genome folds and predicts how the fold will change upon editing the DNA, allowing us now to engineer genomes in 3D.
My research also spans multiple areas of biology. In work with Ron Dror and Brian Kobilka, using atomic-level molecular simulations and an active-state crystal structure we describe a novel mechanism for structural activation of the mu-opioid receptor, a G protein-coupled receptor. I also worked with Karl Deisseroth, analyzing 3D images of cleared mouse brains and neural network dynamics in live zebrafish brains.
I graduated from Harvard in 2011 where I majored in mathematics and minored in computer science. My thesis derived a novel symmetry - that fractal curves linearly transform the dimension of all subsets. I also completed a masters degree in 2014 at New England Conservatory where I studied flute with Paula Robison. Check out some past flute performances.