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I am a computer science Ph.D. student at Stanford University in the lab of Roger Kornberg, where I use high-throughput experiments and machine learning to study protein function and transcriptional regulation. My work spans experimental and computational disciplines, including genomics, molecular biology, biochemistry, microscopy, deep learning, bioinformatics, and molecular simulation. My recent preprint describes the sequence, structure, and function landscape of the activating domains in transcription factor proteins. I was an Accel Innovation Scholar (2018-19) and a NDSEG Fellowship winner (2015-18).

I have also worked closely with Erez Lieberman Aiden to study how the two-meter-long human genome folds inside the microscopic cell nucleus and its implications for gene regulation.
We proposed that chromatin forms loops and domains through a process of loop extrusion and used molecular dynamics simulations to predict how the fold will change upon editing the DNA, allowing us to engineer genomes in 3D. Loop extrusion was subsequently demonstrated by others in single-molecule experiments!

I did my undergrad at Harvard where I majored in mathematics and minored in computer science. I also completed a masters degree at New England Conservatory where I studied flute performance with Paula Robison.


Contact: a <at> adriansanborn.com